PRESENTATIONS
Prepared by: Chelsea L. Rahiman, Roberto A. Ribas, Chang Liu, Julia An, Patrick J. McCann, Manan Vij, Jason Cham, Rosa Martín-Pérez, Ariel Chen, Parin Shah, Aleksandar Z. Obradovic,
Simon Cheng, Ramon C. Sun, Catherine S. Spina
This poster integrates spatial metabolomics and single-nuclear RNA sequencing to investigate metabolism and immune regulation in NSCLC tumors, revealing how adenosine signaling drives immune suppression and uncovering potential new therapeutic targets.
Prepared by: Krishan K. Saini, Samanta Sarti, Chelsea L. Rahiman, Brian E. Ragaishis, Patrick J. McCann, Shruti Bansal, Jason Cham, Julia An, Rosa Martin, Ariel Chen, Catherine S. Spina
This poster explores how radiation affects immune responses and adenosine signaling in lung cancer, offering insights to improve future immuno-radiotherapy approaches.
Prepared by: Krishan K. Saini, Samanta Sarti, Chelsea L. Rahiman, Brian E. Ragaishis, Patrick J. McCann, Shruti Bansal, Jason Cham, Julia An, Rosa Martin, Ariel Chen, Catherine S. Spina
This poster explores how tumor- and host-derived adenosine affect radiosensitivity in breast cancer models. It shows that radiation increases adenosine levels, and that loss of CD73 in tumor—but not host—cells improves response. Targeting CD73 and adenosine receptors may enhance tumor control.
Prepared by: Kristine P. Lacuna, Julia An, Chelsea Rahiman, Shing M. Lee, Liner Ge, Mark N. Stein, Noor Ahmad, Karie Runcie, Alexander Z. Wei, Catherine S. Spina
This poster presents the design and rationale of a phase 2 trial evaluating stereotactic body radiation therapy (SBRT) combined with adenosine signaling modulators and immune checkpoint inhibition in men with hormone-sensitive oligometastatic prostate cancer.